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KMID : 0043320150380010011
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Archives of Pharmacal Research
2015 Volume.38 No. 1 p.11 ~ p.17
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Inhibition of matrix metalloproteinase-1 and type-I procollagen expression by phenolic compounds isolated from the leaves of Quercus mongolica in ultraviolet-irradiated human fibroblast cells
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Kim Han-Hyuk
Kim Dong-Hee
Oh Myeong-Hwan
Park Kwang-Jun
Heo Jun-Hyeok
Lee Min-Won
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Abstract
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The aim of this study was to investigate the effect of Quercus mongolica (QM) which induce anti-photoaging process of skin in vitro. Bioassay-guided isolation of 80 % Me2CO extract of the leaves of QM led to the isolation and identification of six known phenolic compounds: pedunculagin (1), (?)-epigallocatechin (2), (+)-catechin (3), quercetin 3-O-(6″-O-galloyl)-β-d-glucopyranoside (4), kaempferol-3-O-β-d-glucopyranoside-7-O-α-l-rhamnopyranoside (5) and kaempferol 3-O-(6″-galloyl)-β-d-glucopyranoside (6). The effects of compounds 1?6 on expression of matrix metalloproteinase-1 (MMP-1) and type-I procollagen were further evaluated. Among them, compound 1 showed potent inhibitory effect on MMP-1 and the increased type-I procollagen synthesis in ultraviolet B-induced human fibroblast. These results suggest that pedunculagin, an ellagitannin, is a potential candidate for the prevention and treatment of skin aging.
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KEYWORD
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Quercus mongolica, Ellagitannin, Flavonoid, Ultraviolet, Matrix metalloproteinase-1, CCD-986sk cells
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